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hct116 myc reporter luc cells  (BPS Bioscience)


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    BPS Bioscience hct116 myc reporter luc cells
    a, Venn diagram depicting total number of shared and unique peptides analyzed between STR116 and tetracycline treated P493–6 cells. b, Bar graph of the average median change in expression of indicated number of proteins analyzed for individual datasets. c, DAVID-GO analyses indicating clusters of relevant upregulated (c, red, top) and downregulated (d, blue, bottom) proteins shared between STR116 and tetracycline treated P493–6 cells. P-values for SILAC ratios were calculated using a background-based t-test. e, Firefly luciferase activity in <t>HCT116</t> E-box reporter cells measured after STR treatment (20 μM for 24 hr). Data shown represent mean and s.d. of n = 3 independent biological replicates. Statistical analyses are by unpaired, two-sided t test. f, Representative western blot analysis of P493–6 cells after 48 hr treatment with indicated combinations of vehicle (‘MYC-ON’), tetracycline (‘MYC-OFF’) and 20 μM STR116 or STR118. g, Viability of P493–6 cells treated with STR116 under conditions of low (left, ‘MYC-OFF’) or high MYC expression (right, ‘MYC-ON’) after 72 hr. h, i, Relative viability of Ramos (h) or Jurkat (i) cells treated with STR116 after 72 hr. Viability plots show mean and s.d. for n = 3 independent biological replicates.
    Hct116 Myc Reporter Luc Cells, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/hct116 myc reporter luc cells/product/BPS Bioscience
    Average 92 stars, based on 6 article reviews
    hct116 myc reporter luc cells - by Bioz Stars, 2026-03
    92/100 stars

    Images

    1) Product Images from "Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains"

    Article Title: Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains

    Journal: Nature biotechnology

    doi: 10.1038/s41587-022-01504-x

    a, Venn diagram depicting total number of shared and unique peptides analyzed between STR116 and tetracycline treated P493–6 cells. b, Bar graph of the average median change in expression of indicated number of proteins analyzed for individual datasets. c, DAVID-GO analyses indicating clusters of relevant upregulated (c, red, top) and downregulated (d, blue, bottom) proteins shared between STR116 and tetracycline treated P493–6 cells. P-values for SILAC ratios were calculated using a background-based t-test. e, Firefly luciferase activity in HCT116 E-box reporter cells measured after STR treatment (20 μM for 24 hr). Data shown represent mean and s.d. of n = 3 independent biological replicates. Statistical analyses are by unpaired, two-sided t test. f, Representative western blot analysis of P493–6 cells after 48 hr treatment with indicated combinations of vehicle (‘MYC-ON’), tetracycline (‘MYC-OFF’) and 20 μM STR116 or STR118. g, Viability of P493–6 cells treated with STR116 under conditions of low (left, ‘MYC-OFF’) or high MYC expression (right, ‘MYC-ON’) after 72 hr. h, i, Relative viability of Ramos (h) or Jurkat (i) cells treated with STR116 after 72 hr. Viability plots show mean and s.d. for n = 3 independent biological replicates.
    Figure Legend Snippet: a, Venn diagram depicting total number of shared and unique peptides analyzed between STR116 and tetracycline treated P493–6 cells. b, Bar graph of the average median change in expression of indicated number of proteins analyzed for individual datasets. c, DAVID-GO analyses indicating clusters of relevant upregulated (c, red, top) and downregulated (d, blue, bottom) proteins shared between STR116 and tetracycline treated P493–6 cells. P-values for SILAC ratios were calculated using a background-based t-test. e, Firefly luciferase activity in HCT116 E-box reporter cells measured after STR treatment (20 μM for 24 hr). Data shown represent mean and s.d. of n = 3 independent biological replicates. Statistical analyses are by unpaired, two-sided t test. f, Representative western blot analysis of P493–6 cells after 48 hr treatment with indicated combinations of vehicle (‘MYC-ON’), tetracycline (‘MYC-OFF’) and 20 μM STR116 or STR118. g, Viability of P493–6 cells treated with STR116 under conditions of low (left, ‘MYC-OFF’) or high MYC expression (right, ‘MYC-ON’) after 72 hr. h, i, Relative viability of Ramos (h) or Jurkat (i) cells treated with STR116 after 72 hr. Viability plots show mean and s.d. for n = 3 independent biological replicates.

    Techniques Used: Expressing, Luciferase, Activity Assay, Western Blot



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    a, Venn diagram depicting total number of shared and unique peptides analyzed between STR116 and tetracycline treated P493–6 cells. b, Bar graph of the average median change in expression of indicated number of proteins analyzed for individual datasets. c, DAVID-GO analyses indicating clusters of relevant upregulated (c, red, top) and downregulated (d, blue, bottom) proteins shared between STR116 and tetracycline treated P493–6 cells. P-values for SILAC ratios were calculated using a background-based t-test. e, Firefly luciferase activity in <t>HCT116</t> E-box reporter cells measured after STR treatment (20 μM for 24 hr). Data shown represent mean and s.d. of n = 3 independent biological replicates. Statistical analyses are by unpaired, two-sided t test. f, Representative western blot analysis of P493–6 cells after 48 hr treatment with indicated combinations of vehicle (‘MYC-ON’), tetracycline (‘MYC-OFF’) and 20 μM STR116 or STR118. g, Viability of P493–6 cells treated with STR116 under conditions of low (left, ‘MYC-OFF’) or high MYC expression (right, ‘MYC-ON’) after 72 hr. h, i, Relative viability of Ramos (h) or Jurkat (i) cells treated with STR116 after 72 hr. Viability plots show mean and s.d. for n = 3 independent biological replicates.
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    MYC-luciferase reporter assay: ( A ) MYC-luciferase reporter assay in stable transfected <t>HCT-116</t> cells treated with various concentrations of TCH-165 (EC 50 2.57 μM; 95% CI 2.46–2.95); ( B ) MYC-luciferase reporter assay in stably transfected HCT-116 cells treated with vehicle, TCH-165 (3 μM), bortezomib (BTZ, 10 nM) and bortezomib (2 h pre-incubation, 10 nM) followed by TCH-165 (3 μM). *** p < 0.001.
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    Image Search Results


    a, Venn diagram depicting total number of shared and unique peptides analyzed between STR116 and tetracycline treated P493–6 cells. b, Bar graph of the average median change in expression of indicated number of proteins analyzed for individual datasets. c, DAVID-GO analyses indicating clusters of relevant upregulated (c, red, top) and downregulated (d, blue, bottom) proteins shared between STR116 and tetracycline treated P493–6 cells. P-values for SILAC ratios were calculated using a background-based t-test. e, Firefly luciferase activity in HCT116 E-box reporter cells measured after STR treatment (20 μM for 24 hr). Data shown represent mean and s.d. of n = 3 independent biological replicates. Statistical analyses are by unpaired, two-sided t test. f, Representative western blot analysis of P493–6 cells after 48 hr treatment with indicated combinations of vehicle (‘MYC-ON’), tetracycline (‘MYC-OFF’) and 20 μM STR116 or STR118. g, Viability of P493–6 cells treated with STR116 under conditions of low (left, ‘MYC-OFF’) or high MYC expression (right, ‘MYC-ON’) after 72 hr. h, i, Relative viability of Ramos (h) or Jurkat (i) cells treated with STR116 after 72 hr. Viability plots show mean and s.d. for n = 3 independent biological replicates.

    Journal: Nature biotechnology

    Article Title: Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains

    doi: 10.1038/s41587-022-01504-x

    Figure Lengend Snippet: a, Venn diagram depicting total number of shared and unique peptides analyzed between STR116 and tetracycline treated P493–6 cells. b, Bar graph of the average median change in expression of indicated number of proteins analyzed for individual datasets. c, DAVID-GO analyses indicating clusters of relevant upregulated (c, red, top) and downregulated (d, blue, bottom) proteins shared between STR116 and tetracycline treated P493–6 cells. P-values for SILAC ratios were calculated using a background-based t-test. e, Firefly luciferase activity in HCT116 E-box reporter cells measured after STR treatment (20 μM for 24 hr). Data shown represent mean and s.d. of n = 3 independent biological replicates. Statistical analyses are by unpaired, two-sided t test. f, Representative western blot analysis of P493–6 cells after 48 hr treatment with indicated combinations of vehicle (‘MYC-ON’), tetracycline (‘MYC-OFF’) and 20 μM STR116 or STR118. g, Viability of P493–6 cells treated with STR116 under conditions of low (left, ‘MYC-OFF’) or high MYC expression (right, ‘MYC-ON’) after 72 hr. h, i, Relative viability of Ramos (h) or Jurkat (i) cells treated with STR116 after 72 hr. Viability plots show mean and s.d. for n = 3 independent biological replicates.

    Article Snippet: HCT116 MYC Reporter (Luc) cells were purchased from BPS Bioscience (60520).

    Techniques: Expressing, Luciferase, Activity Assay, Western Blot

    MYC-luciferase reporter assay: ( A ) MYC-luciferase reporter assay in stable transfected HCT-116 cells treated with various concentrations of TCH-165 (EC 50 2.57 μM; 95% CI 2.46–2.95); ( B ) MYC-luciferase reporter assay in stably transfected HCT-116 cells treated with vehicle, TCH-165 (3 μM), bortezomib (BTZ, 10 nM) and bortezomib (2 h pre-incubation, 10 nM) followed by TCH-165 (3 μM). *** p < 0.001.

    Journal: Biomedicines

    Article Title: Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

    doi: 10.3390/biomedicines10050938

    Figure Lengend Snippet: MYC-luciferase reporter assay: ( A ) MYC-luciferase reporter assay in stable transfected HCT-116 cells treated with various concentrations of TCH-165 (EC 50 2.57 μM; 95% CI 2.46–2.95); ( B ) MYC-luciferase reporter assay in stably transfected HCT-116 cells treated with vehicle, TCH-165 (3 μM), bortezomib (BTZ, 10 nM) and bortezomib (2 h pre-incubation, 10 nM) followed by TCH-165 (3 μM). *** p < 0.001.

    Article Snippet: The MYC Reporter (Luc)-HCT-116 Cell line, Catalog #60520, was bought from BPS Bioscience.

    Techniques: Luciferase, Reporter Assay, Transfection, Stable Transfection, Incubation